This funded PhD research project tries to explain the fundamental mechanism of the transcription-translation coupling in bacteria. Also, the structural biology studies will enhance the modern knowledge of the lead ribosome closely trails the RNA polymerase (RNAP). Which focuses on doctoral research projects focus on the mechanical transcription-translation in bacteria.
Facilities:
Students get benefited out of the latest facilities of CEITEC, which follows:
- X-ray crystallography
- cryo-EM equipment
- High-field NMR systems.
- Biomolecular equipment
Requirements of the PhD Project in Structural Biology
It required that applicants should focus on the structural and functional identification of the factors needed to couple transcription and translation in bacteria.
Structural biology studies of various states of direct and bridged transcription-translation coupling in vitro and in vivo
Qualifications for the PhD project
The PhD candidate who holds MSc. in molecular biology or biochemistry and run the biochemical assays, or who trained in structural biology, mainly single-particle cryo-EM or cryo-electron tomography (cryo-ET).
The candidate should be able to purify the components for fundamental studies of transcription-translation coupling and run the biochemical assays. The candidate should be a motivated person with a collaborative mindset.
How to Apply
To apply, please contact the supervisor and submit a CV by email to [email protected]
Deadline: April 19, 2020
More information:
Structural Biology of Coupled Transcription-Translation – Gabriel Demo
